Water → HCID 53801683, compound

Participants

Reaction Conditions

Reaction Steps

This Example illustrates the preparation of compound no. 3 of Table I. 1,2,4-Triazole (4.64 g) in dry dimethylformamide (10 ml) was added slowly to a suspension of sodium hydride (2.88 g of 50% dispersion in mineral oil, washed free of oil with dry petrol) in dry dimethylformamide (10 ml) with cooling and stirring. A solution of 1-benzoyl-1,2-dibromo-2-(o-chlorophenyl) ethane (8.45 g) in dry dimethylformamide (10 ml) was then added and the mixture heated at 100° C. for 1 hour. The mixture was poured into cold water (1 liter) and extracted with ether. The ether extracts were dried and evaporated to give a yellow oil. This was dissolved in hexane and the solution cooled to -15° C. The light yellow fibrous crystals were filtered off to give 1-benzoyl-2-o-chlorophenyl-2-(1,2,4-triazol-1-yl)-ethylene (compound no. 3 of Table I) having a melting point of 79°-81° C.

Provenance & Evidence