HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 59639568, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Oxolan-3-amine--hydrogen chloride (1/1) | HCID 22239904 | — |
| Reactant | 8-(2,6-difluoro-phenyl)-4-(4-fluoro-2-methyl-phenyl)-2-methanesulfonyl-8H-pyrido[2,3-d]pyrimidin-7-one | HCID 59639554 | — |
| Product | HCID 59639568 | HCID 59639568 | 30% |
Reaction Steps
Following the general procedure outlined in Example 195, the product of Example 48 (125 mg, 0.28 mmol), the crude tetrahydro-furan-3-ylamine hydrochloride (240 mg) and triethylamine (0.27 mL, 1.9 mmol) were reacted to give the crude material. Purification by flash chromatography, eluting with EtOAc/hexane/triethylamine (50/50/2, v/v/v), gave the desired product (38 mg, 30%). LC-MS: 453.2 (MH+, m/z), 2.20 (Rt, min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07314934B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-77dfdfba3bc3434f8186b4ebf1650bfc |
| Source note | uspto-grants-2008_01 |