Acetone → HCID 44412650, compound

HRID 2250118Notes

Reaction equation

HRID 2250118 reaction equation
Cl.Cl.[N:3]1([CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:22]=[C:21]3[C:16]([CH2:17][CH2:18][NH:19][CH2:20]3)=[CH:15][CH:14]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[CH3:23][C:24]([CH3:26])=O>>[CH:24]([N:19]1[CH2:18][CH2:17][C:16]2[C:21](=[CH:22][C:13]([O:12][CH2:11][CH2:10][CH2:9][N:3]3[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]3)=[CH:14][CH:15]=2)[CH2:20]1)([CH3:26])[CH3:23]

Participants

3

Reactant 2

HCID 180AcetoneHCID 69311509HCID 69311509, compound

Product 1

HCID 44412650HCID 44412650, compound

Procedure

2-Isopropyl-7-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-isoquinoline is prepared from 7-(3piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-isoquinoline dihydrochloride (520 mg, 1.5 mmol), MP-CNBH3 (3.2 g, 7.5 mmol), and acetone (1.1 mL, 15 mmol) via a procedure substantially analogous to Procedure C except that the SCX column is not used in purification. The product (210 mg, 44% yld) is isolated as a clear oil. MS(ES+)317.2(M+H)+.

Workup

  1. customis not used in purification
  2. customThe product (210 mg, 44% yld) is isolated as a clear oil

Sources & evidence

ORD record
ord-e2c7d8dca97743f892e75654b24fb992
Source dataset
uspto-grants-2008_01
Patent number
US07314937B2

Reaction notes

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