Tris(hydroxymethyl)aminomethane → HCID 69308498, compound

Participants

Reaction Steps

To a 4 mL vial is placed 6-(3-piperidin-1-yl-propoxy)-1,2,3,4-tetrahydro-isoquinoline dihydrochloride (25.0 mg, 0.07 mmol), resin-bound Hunigs base (81 mg, 0.29 mmol, 3.54 mmol/g), resin bound DMAP (catalytic), and dry CH2Cl2 and isopropyl isocyanate (16□L, 0.18 mmol). The vial is agitated by means of a lab quake shaker overnight. In the morning, PS-trisamine (120 mg, 0.36 mmol, 3.0 mmol/g) is added and the reaction again allowed to rotate for 4 hours to scavenge excess isocyanate., Filtration, washing with CH2Cl2 and concentration afforded the desired urea. M+1 360.

Provenance & Evidence