1,4-Dioxane hydrochloride → HCID 69308526, compound

HRID 2250142Notes

Reaction equation

HRID 2250142 reaction equation
C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][Cl:23])=[CH:13][CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:24].O1[CH2:30][CH2:29]OCC1>>[ClH:23].[ClH:24].[N:8]1([CH2:22][CH2:21][CH2:20][CH2:19][O:18][C:12]2[CH:11]=[C:10]3[C:15]([CH2:16][CH2:17][NH:8][CH2:9]3)=[CH:14][CH:13]=2)[CH2:30][CH2:29][CH2:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86592736HCID 86592736, compound

Product 1

HCID 69308526HCID 69308526, compound

Procedure

7-(4-Piperidin-1-yl-butoxy)-1,2,3,4-tetrahydro-isoquinoline dihydrochloride is prepared from 7-(4-chloro-butoxy)-3,4-dihydro-1-H-isoquinoline-2-carboxylic acid tert-butyl ester (600 mg, 1.5 mmol) and 4N HCl/dioxane (2.5 mL, 10 mmol) base in a manner substantially analogous to Procedure B to give the product (490 mg, 90% yld). MS(ES+)389.3 (M+H)+ free

Workup

  1. customto give the product (490 mg, 90% yld)

Sources & evidence

ORD record
ord-d243f5dfb4f14844bf1905966b21b91a
Source dataset
uspto-grants-2008_01
Patent number
US07314937B2

Reaction notes

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