Dimethylformamide → HCID 59640447, compound

Participants

Reaction Steps

An 8 mL DMF solution of [4-(4-bromo-butoxy)-benzyl]-(2-pyrrolidin-1-yl-ethyl)-amine (307 mg, 0.86 mmol) and piperidine (0.22 mL, 2.2 mmol) is stirred at 90° C. for six hours under N2. The reaction mixture is cooled, diluted with CH2Cl2, filtered, washed with brine, dried (Na2SO4), and concentrated. The residue is purified by chromatography (SiO2; 0-6% MeOH/CH2Cl2/1% NH4OH gradient) to give the product (40 mg, 12% yld). MS(ES+)360.4(M+H)+ free base.

Provenance & Evidence