HCID 58864337, compound → HCID 58864456, compound

HRID 2250194Notes

Reaction equation

HRID 2250194 reaction equation
[O:1]=[C:2]1[N:11]([CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][C@H:21]([CH2:25][C:26]3[CH:27]=[C:28]4[C:32](=[CH:33][CH:34]=3)[N:31](S(CC[Si](C)(C)C)(=O)=O)N=C4)[C:22]([OH:24])=[O:23])=[O:19])[CH2:14][CH2:13]2)[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.[OH-:44].[Li+].CO.[O:48]1[CH2:52]CCC1.O>>[O:44]=[C:52]1[NH:31][C:32]2[CH:33]=[CH:34][C:26]([CH2:25][C@@H:21]([NH:20][C:18]([N:15]3[CH2:16][CH2:17][CH:12]([N:11]4[CH2:10][C:9]5[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=5)[NH:3][C:2]4=[O:1])[CH2:13][CH2:14]3)=[O:19])[C:22]([OH:24])=[O:23])=[CH:27][C:28]=2[O:48]1

Participants

3

Reactant 2

HCID 58864337HCID 58864337, compoundHCID 68706663HCID 68706663, compound

Product 1

HCID 58864456HCID 58864456, compound

Procedure

Prepared as described above for (R)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-3-[1-(2-trimethylsilanyl-ethanesulfonyl)-1H-indazol-5-yl]-propionic acid. The hydrolysis conditions (lithium hydroxide/methanol-tetrahydrofuran-water (1:1:1) at −15° C. overnight were used. The title compound was obtained as a white solid (95%). Mass spec.: 480.30 (MH)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-81325d102ab24c01b8349160a680de11
Source dataset
uspto-grants-2008_01
Patent number
US07314883B2

Reaction notes

Loading…