反应详情

温度

60 °C

(1-Benzyl-piperidin-4-yl)-(2-nitro-benzyl)-amine (0.25 g, 0.7 mmol) and zinc dust (0.2 g, excess) were combined in 75% aqueous acetic acid (8 mL) and stirred at 60° C. for 2 h. After cooling to room temperature, the solvents were removed in vacuo and the resultant crude mixture dissolved in water (10 mL), followed by addition of ammonium hydroxide until pH 3 was attained. The solution was extracted with methylene chloride (3×). The organic layers were pooled together, washed with water (2×), brine (2×), dried over sodium sulfate, filtered, and concentrated to afford 0.18 g (79%) of the desired product.

1. temperatureAfter cooling to room temperature
2. customthe solvents were removed in vacuo
3. dissolutionthe resultant crude mixture dissolved in water (10 mL)
4. additionfollowed by addition of ammonium hydroxide until pH 3
5. extractionThe solution was extracted with methylene chloride (3×)
6. washwashed with water (2×), brine (2×)
7. dry with materialdried over sodium sulfate
8. filtrationfiltered
9. concentrationconcentrated