Dimethylamine → HCID 23328745, compound

Participants

Reaction Steps

To a suspension of 2.0 parts of 1-bromomethyl-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine 5-oxide in 20 volume parts of dimethylformamide is added 5 volume parts of 40 weight % aqueous solution of dimethylamine under stirring, and the resulting solution is stirred for 30 minutes at room temperature. After removing the solvent, the crystalline residue is recrystallized from ethyl alcohol to give 8-chloro-1-dimethylaminomethyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine 5-oxide as colorless prisms melting at 217° to 219° C.

Provenance & Evidence