反应详情

To a solution of BH3.THF (2.2 mL, 2.2 mmol) cooled to 0° C. was added compound 4a (100 mg, 0.3 mmol). The resulting mixture was stirred for 30 min, then warmed to room temperature and stirred overnight. The reaction was quenched with water, and extracted with Et2O. The organic solution was dried over Na2SO4 and concentrated under vacuum to provide 5a (85.2 mg, 89%) which was used directly without further purification. 1H NMR (500 MHz, CD3OD) δ 1.39 (m, 2H), 1.45 (m, 4H), 1.62 (m, 1H), 1.71 (m, 2H), 1.95 (m, 2H), 2.87 (m, 2H), 2.97 (m, 2H), 3.25 (m, 2H), 3.45 (d, 2H), 3.82 (m, 2H), 4.61 (s, 2H), 7.39 (m, 5H). m/z (ESI): 291 [C18H30N2O+H]+.

1. stirringstirred overnight
2. customThe reaction was quenched with water
3. extractionextracted with Et2O
4. dry with materialThe organic solution was dried over Na2SO4
5. concentrationconcentrated under vacuum