Methyl 4-(piperidin-4-yl)butanoate → HCID 69288049, compound

HRID 2250320Notes

Reaction equation

HRID 2250320 reaction equation
[CH3:1][O:2][C:3](=[O:23])[CH2:4][CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][CH2:14]OCC2C=CC=CC=2)[CH2:9][CH2:8]1.[CH3:24][O:25][C:26](=O)[CH2:27][CH2:28][CH2:29][CH:30]1[CH2:35][CH2:34]NCC1>>[CH3:1][O:2][C:3](=[O:23])[CH2:4][CH2:5][CH2:6][CH:7]1[CH2:8][CH2:9][N:10]([CH2:13][CH2:14][CH2:24][O:25][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:35][CH:34]=2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 21462751Methyl 4-(piperidin-4-yl)butanoateHCID 69286828HCID 69286828, compound

Product 1

HCID 69288049HCID 69288049, compoundYield 40%

Procedure

Following the same procedure described for the preparation of compound 3a, the compound 3b was synthesized in 40% yield from compound 2 as a yellow oil. 1H NMR (300 MHz, CD3OD) δ 1.21 (m, 4H), 1.42 (m, 1H), 1.49 (m, 2H), 1.83 (d, 2H), 1.93 (m, 2H), 2.31 (m, 2H), 2.69 (m, 2H), 2.99 (m, 2H), 3.35 (m, 2H), 3.60 (m, 5H), 4.50 (m, 2H), 7.28 (m, 5H). m/z (ESI): 334 [C20H31NO3+H]+.

Sources & evidence

ORD record
ord-44ac39d043914e638ce6c7a073878801
Source dataset
uspto-grants-2008_01
Patent number
US07317013B2

Reaction notes

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