反应详情

温度

70 °C

A mixture of 6-amino-3-butyl-1,3-dihydropyrimidine-2,4-dione (4.0 g, 21.8 mmol) and aqueous acetic acid (120 ml) was heated at 70° C. until complete solution as attained, and the solution was cooled to 30° C. Sodium nitrite (3 g) was added in small portions while stirring, forming an orange precipitate. The reaction mixture was cooled to 0° C., and the precipitate filtered off, washed with water, and dried under reduced pressure, to provide 5-nitroso-6-amino-3-butyl-1,3-dihydropyrimidine-2,4-dione, which was used in the next reaction with no further purification.

1. temperaturethe solution was cooled to 30° C
2. customforming an orange precipitate
3. temperatureThe reaction mixture was cooled to 0° C.
4. filtrationthe precipitate filtered off
5. washwashed with water
6. customdried under reduced pressure