2-Fluoropyridine-3-boronic acid → HCID 15603654, compound

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The title compound (41 mg, 42%) as a yellow solid was prepared from 6-chloro-7-(4-chlorophenyl)-2-((6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (88 mg, 0.2 mmol) and 2-fluoropyridin-3-ylboronic acid (56 mg, 0.4 mmol) according to the procedures described for 7-(4-chlorophenyl)-6-phenyl-2-((6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (Example 9). LC/MS (method A): retention time=3.38 min, (M+H)+=501. 1H NMR (CDCl3, 400 MHz): δ 8.84 (s, 1H), 8.14 (d, J=1.96 Hz, 1H), 7.97-8.01 (m, 1H), 7.68-7.76 (m, 2H), 7.46 (s, 1H), 7.34 (d,J=8.56 Hz, 2H), 7.04 (d,J=8.56 Hz, 2H), 6.89 (dd,J=8.56, 2.93 Hz, 1H), 5.34 (s, 2H).

Provenance & Evidence