p-Trifluoromethylbenzyl chloride → HCID 58772594, compound

Participants

Reaction Steps

The title compound (469 mg, 60%) was prepared from 6-chloro-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (500 mg, 1.78 mmol) and 1-chloromethyl-4-trifluoromethyl benzene (425 mg, 1.78 mmol) according to the procedures described for 6-chloro-7-(4-chlorophenyl)-2-((6-(trifluoromethyl)pyridin-3-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (Example 8E). LC/MS (Method C): retention time=3.91 min, (M+H)+=439.

Provenance & Evidence