Acetic Acid → HCID 178475873, compound

HRID 2250368Notes

Reaction equation

HRID 2250368 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH2:9][CH2:10][C:11]2[NH:19][C:14]3=[N:15][CH:16]=[CH:17][CH:18]=[C:13]3[N:12]=2)[N:3]=1.[C:20]([OH:23])(=[O:22])[CH3:21]>ClCCl>[C:20]([OH:23])(=[O:22])[CH3:21].[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH2:9][CH2:10][C:11]2[NH:19][C:14]3=[N:15][CH:16]=[CH:17][CH:18]=[C:13]3[N:12]=2)[N:3]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 178428715HCID 178428715, compound2×

Product 1

HCID 178475873HCID 178475873, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

52 mg of 2-[2-(2-Amino-4-methylpyridin-6-yl)ethyl]-3H-imidazo[4,5-b]pyridine (compound 1) are dissolved in 25 ml of dichloromethane. 2 ml of aqueous acetic acid (50% strength) are added. The mixture is concentrated and coevaporated successively with water and dichloromethane to give 65 mg of the title compound as foam. M.p. 54° C. MS: 254.2 (MH+), 528.8 (2MNa+).

Workup

  1. concentrationThe mixture is concentrated

Sources & evidence

ORD record
ord-621e5124a2bf45ba8faf45334a6bdc9a
Source dataset
uspto-grants-2008_01
Patent number
US07317021B2

Reaction notes

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