HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2250384Generated: October 30, 2026
N-[2-Amino-5-(4-chloro-phenyl)-pyridin-3-yl]3-[4-methyl-6-(trityl-amino)-pyridin-2-yl]-propionamide → N-[2-Amino-5-(4-chloro-phenyl)-pyridin-3-yl]-3-(6-amino-4-methyl-pyridin-2-yl)-propionamide
https://huagongshe.com/reaction/2250384
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-[2-Amino-5-(4-chloro-phenyl)-pyridin-3-yl]3-[4-methyl-6-(trityl-amino)-pyridin-2-yl]-propionamide | HCID 68465037 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-[2-Amino-5-(4-chloro-phenyl)-pyridin-3-yl]-3-(6-amino-4-methyl-pyridin-2-yl)-propionamide | HCID 68466161 | 14.5% |
Reaction Steps
405 mg of N-[2-amino-5-(4-chloro-phenyl)-pyridin-3-yl]-3-[4-methyl-6-(trityl-amino)-pyridin-2-yl]-propionamide (compound B8) are dissolved in 24 ml of aqueous acetic acid (50% strength) and heated at 80° C. for 3 h. Subsequent workup according to the procedure described herein for example B5 yields 36 mg of the title compound as an oil. ESI-MS: 382.2/384.2 (MH+, 100%/360%). TLC: Rf=0.40 (dichloromethane/methanol 10:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07317021B2 |
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| Source dataset | uspto-grants-2008_01 |
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| ORD ID | ord-6cfb2954311d4948b3110e655d882df6 |
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| Source note | uspto-grants-2008_01 |
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