HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalic Anhydride → 2-[2-(4-Iodophenyl)ethyl]-1H-isoindole-1,3(2H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalic Anhydride | HCID 6811 | — |
| Reactant | 2-(4-Iodophenyl)ethylamine | HCID 15150145 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-[2-(4-Iodophenyl)ethyl]-1H-isoindole-1,3(2H)-dione | HCID 68538378 | 64.8% |
Reaction Steps
A solution of 2-(4-iodophenyl)ethylamine (7.08 g) and phthalic anhydride (4.24 g) in acetic acid (100 mL) was refluxed for 4 h. The solvent was evaporated and the residue triturated with ethanol (100 mL). The solid was filtered to afford the title intermediate (7.0 g) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07317023B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-e20e5c2e08e344e5a72cc7bb57a90eb7 |
| Source note | uspto-grants-2008_01 |