Hydrochloric Acid → HCID 67012312, compound

Participants

Reaction Steps

To a solution of 810 mg (1.236 mmol) of 1-(6-Chloro-benzo[b]thiophen-2-ylmethyl)-5-(2-methoxy-ethoxy)-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide hydrochloride in 80 mL CH2Cl2 2.472 mL of a 1M solution of BBr3 in CH2Cl2 were added. The mixture was stirred at room temperature for 30 min. The solvent was removed in vacuo and lyophilized. The residue was purified by preparative HPLC (eluent: CH3CN/H2O/0.1% CF3COOH). The fractions containing the product were combined, concentrated in vacuo and lyophilized with 2.5 equivalents of 1N HCl yielding the hydrochloride salt of the desired product.

Provenance & Evidence