(2-Amino-3-chlorophenyl)amine → N-(2-Amino-3-chlorophenyl)-N'-(4-methyl-3-thienyl)thiourea

HRID 2250491Notes

Reaction equation

HRID 2250491 reaction equation
[CH3:1][C:2]1[C:3]([N:7]=[C:8]=[S:9])=[CH:4][S:5][CH:6]=1.[Cl:10][C:11]1[C:12]([NH2:18])=[C:13]([NH2:17])[CH:14]=[CH:15][CH:16]=1>>[NH2:18][C:12]1[C:11]([Cl:10])=[CH:16][CH:15]=[CH:14][C:13]=1[NH:17][C:8]([NH:7][C:3]1[C:2]([CH3:1])=[CH:6][S:5][CH:4]=1)=[S:9]

Participants

3

Reactant 2

HCID 3462489(2-Amino-3-chlorophenyl)amineHCID 221398273-Isothiocyanato-4-methylthiophene

Product 1

HCID 22139861N-(2-Amino-3-chlorophenyl)-N'-(4-methyl-3-thienyl)thiourea

Procedure

is obtained analogously to the reaction described in example 1 b) from 4-methyl-3-thienyl isothiocyanate and 3-chloro-1,2-diaminobenzene (prepared by catalytic hydrogenation of 3-chloro-2-nitroaniline using Pt on activated carbon under atmospheric pressure at room temperature). Crystalline solid, m.p. 298-305° C.,

Workup

  1. customis obtained analogously to the reaction

Sources & evidence

ORD record
ord-e5bd12addaee4a078dbbd11eb77a7620
Source dataset
uspto-grants-2008_01
Patent number
US07317033B2

Reaction notes

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