HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → N-(2-Amino-3-methoxyphenyl)-N'-(4-methyl-3-thienyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-Methoxybenzene-1,2-diamine | HCID 184268 | — |
| Reactant | 3-Isothiocyanato-4-methylthiophene | HCID 22139827 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(2-Amino-3-methoxyphenyl)-N'-(4-methyl-3-thienyl)thiourea | HCID 22139816 | — |
Reaction Steps
is obtained analogously to the procedure described in example 25 a) from 3-methoxy-1,2-diaminobenzene and 4-methyl-3-thienyl isothiocyanate in anhydrous THF, followed by medium-pressure chromatography on silica gel using a mixture of 1 part of toluene and 1 part of ethyl acetate. Crystalline solid, m.p.: 148-153° C. Solidification of the melt and next m.p. at 260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07317033B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-1951bb654f3944619e3acc68147333ce |
| Source note | uspto-grants-2008_01 |