Ammonia → HCID 178431887, compound

HRID 2250500Notes

Reaction equation

HRID 2250500 reaction equation
[NH3:1].[O:2]1[C:6]2([CH2:11][CH2:10][CH2:9][CH2:8][CH:7]2[NH:12][C:13](=[N:16][C:17]2[C:21]([CH3:22])=[CH:20][S:19][CH:18]=2)SC)[O:5][CH2:4][CH2:3]1>CO>[O:2]1[C:6]2([CH2:11][CH2:10][CH2:9][CH2:8][CH:7]2[NH:12][C:13]([NH:16][C:17]2[C:21]([CH3:22])=[CH:20][S:19][CH:18]=2)=[NH:1])[O:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178503864HCID 178503864, compound

Product 1

HCID 178431887HCID 178431887, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

In a ReactiVial, a 7 M solution of ammonia in methanol (2 ml) was added to 1-(1,4-dioxaspiro[4.5]dec-6-yl)-2-methyl-3-(4-methylthiophen-3-yl)isothiourea (58.8 mg), and the mixture was heated in a sand bath at about 100° C. for 16 hours. Removal of the solvent gave a residue of 51 mg of an oily product which was directly reacted further.

Workup

  1. customRemoval of the solvent

Sources & evidence

ORD record
ord-b0286c1d9977452989e57718034ba16d
Source dataset
uspto-grants-2008_01
Patent number
US07317033B2

Reaction notes

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