HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 3-(1H-1,3-benzodiazol-2-yl)propan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Product | 3-(1H-1,3-benzodiazol-2-yl)propan-1-amine | HCID 1713151 | — |
Reaction Steps
A mixture of 2-pyrrolidone (42.5 g; 0.5 mole) and o-phenylenediamine (54 g; 0.5 mole) was heated with p-toluenesulfonic acid (4.3 g) at 195°-207° for 6 hrs. while removing water (8.5 g) by distillation. A virtually quantitative yield of 2-(3-aminopropyl)benzimidazole was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04235838 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-4dbeed3a99d447e5a08209c4dd0d58aa |
| Source note | uspto-grants-1980_11 |