Sodium Hydroxide → HCID 68803273, compound

HRID 2250596Notes

Reaction equation

HRID 2250596 reaction equation
[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]3[N:12]([C:25]([CH2:28][CH3:29])=[CH:26][CH:27]=3)[N:13]=[C:14]([CH3:24])[C:15]=2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:6][CH:5]=1)=[O:3].[OH-].[Na+:31]>O>[Na+:31].[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]3[N:12]([C:25]([CH2:28][CH3:29])=[CH:26][CH:27]=3)[N:13]=[C:14]([CH3:24])[C:15]=2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O-:23])=[O:22])=[CH:6][CH:5]=1)=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9930467HCID 9930467, compound

Product 1

HCID 68803273HCID 68803273, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 6-{4-[4-(aminocarbonyl)phenyl]-7-ethyl-2-methylpyrrolo[1,2-b]pyridazin-3-yl}hexanoic acid (590 mg) in water (3 mL) was added 1N sodium hydroxide (15 mL) at ambient temperature. After 5 hours, the mixture became clear solution. The solution was filtered through membrane filter, washed with water (0.4 mL×3), and was freeze dried for 15 hours to give 6-{4-[4-(aminocarbonyl)phenyl]-7-ethyl-2-methylpyrrolo[1,2-b]pyridazin-3-yl}hexanoic acid sodium salt (612 mg, 98.2%) as a pale yellow powder.

Workup

  1. filtrationThe solution was filtered through membrane
  2. filtrationfilter
  3. washwashed with water (0.4 mL×3)
  4. customdried for 15 hours

Sources & evidence

ORD record
ord-7852d2536dca4eb6be26e4f3977978e6
Source dataset
uspto-grants-2008_01
Patent number
US07317009B2

Reaction notes

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