Benzoyl chloride → N-(4,6-difluorobenzo[d]thiazol-2-yl)benzamide

HRID 2250665Notes

Reaction equation

HRID 2250665 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([F:11])[CH:8]=[C:7]([F:12])[C:5]=2[N:6]=1.[C:13](Cl)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[F:12][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:13](=[O:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[S:3][C:4]=2[CH:10]=[C:9]([F:11])[CH:8]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 7374064,6-Difluoro-1,3-benzothiazol-2-amine

Product 1

HCID 5234808N-(4,6-difluorobenzo[d]thiazol-2-yl)benzamide

Procedure

Using 2-amino-4,6-difluoro-benzothiazole and benzoyl chloride the title compound was prepared as a beige solid (82% yield), MS: m/e=290 (M+).

Sources & evidence

ORD record
ord-1d1a0e4c8f3947dfb45da6675bdc4eca
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

Loading…