4-Methoxy-2-aminobenzothiazole → 5-Methyl-thiophene-2-carboxylic acid (4-methoxy-benzothiazol-2-yl)-amide

HRID 2250666Notes

Reaction equation

HRID 2250666 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:5]=2[N:6]=1.[CH3:13][C:14]1[S:18][C:17]([C:19](Cl)=[O:20])=[CH:16][CH:15]=1>N1C=CC=CC=1>[CH3:12][O:11][C:7]1[C:5]2[N:6]=[C:2]([NH:1][C:19]([C:17]3[S:18][C:14]([CH3:13])=[CH:15][CH:16]=3)=[O:20])[S:3][C:4]=2[CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 216224-Methoxy-2-aminobenzothiazoleHCID 27600835-Methylthiophene-2-carbonyl chloride

Product 1

HCID 360012145-Methyl-thiophene-2-carboxylic acid (4-methoxy-benzothiazol-2-yl)-amide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Using 2-amino-4-methoxy-benzothiazole and 5-methyl-thiophene-2-carboxylic acid chloride in pyridine the title compound was obtained as a beige solid (95% yield), MS: m/e=304.1 (M+).

Sources & evidence

ORD record
ord-a992c81674a246279442dd5c247711af
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

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