4-Fluorobenzoyl chloride → HCID 22283385, compound

HRID 2250679Notes

Reaction equation

HRID 2250679 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:5][CH:4]=1.[F:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1>>[F:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([NH:12][C:10]2[S:11][C:7]3[C:6]([O:13][C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=4)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[N:9]=2)=[O:26])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 22283057HCID 22283057, compound

Product 1

HCID 22283385HCID 22283385, compound

Procedure

Using 4-methoxy-7-phenoxy-benzothiazol-2-ylamine and 4-fluoro-benzoyl chloride the title compound was obtained crude, which was chromatographed over SiO2 (Merck 230-400 mesh) eluting with CH2Cl2/EtOAc (1:1), to afford the pure title compound as a white solid (75% yield), MS: m/e=394.1 (M+).

Sources & evidence

ORD record
ord-e45eddc82f7d4c49910e59f3a9637815
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

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