5-Methylthiophene-2-carbonyl chloride → HCID 86584904, compound

HRID 2250680Notes

Reaction equation

HRID 2250680 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:5][CH:4]=1.[CH3:20][C:21]1[S:25][C:24]([C:26](Cl)=[O:27])=[CH:23][CH:22]=1>>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12][C:26]([C:24]3[S:25][C:21]([CH3:20])=[CH:22][CH:23]=3)=[O:27])[S:11][C:7]=2[C:6]([O:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 27600835-Methylthiophene-2-carbonyl chlorideHCID 22283057HCID 22283057, compound

Product 1

HCID 86584904HCID 86584904, compound

Procedure

Using 4-methoxy-7-phenoxy-benzothiazol-2-ylamine and 5-methyl-thiophene-2-carboxylic acid chloride the title compound was obtained crude, which was chromatographed over SiO2 (Merck 230-400 mesh) eluting with CH2Cl2/EtOAc (1:1), to afford the pure title compound as a pale yellow solid (76% yield), MS: m/e=396.0 (M+).

Sources & evidence

ORD record
ord-53c9fb0f7b014ebebbd31e414857c274
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

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