5-Methylthiophene-2-carbonyl chloride → 5-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

HRID 2250703Notes

Reaction equation

HRID 2250703 reaction equation
[CH3:1][C:2]1[S:6][C:5]([C:7](Cl)=[O:8])=[CH:4][CH:3]=1.[NH2:10][C:11]1[S:12][C:13]2[C:19]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:18][CH:17]=[C:16]([O:26][CH3:27])[C:14]=2[N:15]=1>>[CH3:27][O:26][C:16]1[C:14]2[N:15]=[C:11]([NH:10][C:7]([C:5]3[S:6][C:2]([CH3:1])=[CH:3][CH:4]=3)=[O:8])[S:12][C:13]=2[C:19]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 27600835-Methylthiophene-2-carbonyl chlorideHCID 114028614-Methoxy-7-morpholinobenzo[d]thiazol-2-amine

Product 1

HCID 865849135-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amideYield 97%

Procedure

Using 5-methyl-thiophene-2-carbonyl chloride and 2-amino-4-methoxy-7-morpholin-4-yl-benzothiazol the title compound was obtained as a yellow solid in 97% yield. MS: m/e=390 (M+H+).

Sources & evidence

ORD record
ord-159aaa7ee8044b7b8bf0fcdbfa3b194b
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

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