Water → HCID 22283025, compound

HRID 2250724Notes

Reaction equation

HRID 2250724 reaction equation
COC(=O)[NH:4][C:5]1[S:6][C:7]2[C:13]([CH:14]=[CH2:15])=[CH:12][CH:11]=[C:10]([O:16][CH3:17])[C:8]=2[N:9]=1.O>C(O)CO>[CH3:17][O:16][C:10]1[C:8]2[N:9]=[C:5]([NH2:4])[S:6][C:7]=2[C:13]([CH:14]=[CH2:15])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 962WaterHCID 86596309HCID 86596309, compound

Product 1

HCID 22283025HCID 22283025, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Conditions

Temperature
100 °C

Procedure

(4-Methoxy-7-vinyl-benzothiazol-2-yl)-carbamic acid methyl ester was dissolved in ethylenglycol/2N KOH (2:1) and stirred at 100° C. for 3 hrs. Then water was added and the mixture was extracted with CH2Cl2, the organic phase was washed with brine and dried over MgSO4. After evaporation the residue was crystallized from CH2Cl2. White crystals (64%); F.p.: 155-159° C.

Workup

  1. extractionthe mixture was extracted with CH2Cl2
  2. washthe organic phase was washed with brine
  3. dry with materialdried over MgSO4
  4. customAfter evaporation the residue
  5. customwas crystallized from CH2Cl2
  6. custom155-159° C.

Sources & evidence

ORD record
ord-808482668fac4b4d9bea166a1034daa5
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

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