Hydrochloride methanol → HCID 86584931, compound

HRID 2250730Notes

Reaction equation

HRID 2250730 reaction equation
[CH3:1][O:2][C:3](=[O:30])[NH:4][C:5]1[S:6][C:7]2[C:13]([C:14]3[N:15]=[C:16]([CH2:19][NH:20]C(OC(C)(C)C)=O)[S:17][CH:18]=3)=[CH:12][CH:11]=[C:10]([O:28][CH3:29])[C:8]=2[N:9]=1.[ClH:31].CO>>[ClH:31].[CH3:1][O:2][C:3](=[O:30])[NH:4][C:5]1[S:6][C:7]2[C:13]([C:14]3[N:15]=[C:16]([CH2:19][NH2:20])[S:17][CH:18]=3)=[CH:12][CH:11]=[C:10]([O:28][CH3:29])[C:8]=2[N:9]=1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 86584933HCID 86584933, compound

Product 1

HCID 86584931HCID 86584931, compound

Procedure

0.075 g of {7-[2-(tert-butoxycarbonylamino-methyl)-thiazol-4-yl]-4-methoxy-benzothiazol-2-yl}-carbamic acid methyl ester (0.00017 Mol) were stirred in 2 ml of 2.5 M HCl/MeOH for 4 hrs. Upon cooling to room temperature a precipitate formed, which was filtered off, washed with hexane and dried. The title compound was obtained as a white solid (70%), F.p.: 220-230° C.

Workup

  1. customformed
  2. filtrationwhich was filtered off
  3. washwashed with hexane
  4. customdried

Sources & evidence

ORD record
ord-a970230acaef459fa1a895a252283354
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

Loading…