N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide → N-(4-Hydroxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide

HRID 2250751Notes

Reaction equation

HRID 2250751 reaction equation
NC1C=C(N2CCOCC2)C=CC=1O.C[O:16][C:17]1[C:22]2[N:23]=[C:24]([NH:26][C:27](=[O:34])[C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[S:25][C:21]=2[C:20]([N:35]2[CH2:40][CH2:39][O:38][CH2:37][CH2:36]2)=[CH:19][CH:18]=1>>[OH:16][C:17]1[C:22]2[N:23]=[C:24]([NH:26][C:27](=[O:34])[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)[S:25][C:21]=2[C:20]([N:35]2[CH2:36][CH2:37][O:38][CH2:39][CH2:40]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 10155957N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamideHCID 222830622-amino-4-(4-morpholinyl)Phenol

Product 1

HCID 22283399N-(4-Hydroxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide

Procedure

The title compound was prepared using 2-amino-4-morpholin-4-yl-phenol as described for N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-benzamide and obtained as a light brown solid in 14% overall yield, MS: m/e=356(M+H+).

Workup

  1. customobtained as a light brown solid in 14% overall yield, MS

Sources & evidence

ORD record
ord-696cfb656864458f87fcd9179a08935f
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

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