4-(Chloromethyl)pyridinium chloride → N-Methylpyridine-4-methylamine

HRID 2250787Notes

Reaction equation

Cl.Cl[CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1.[CH3:10][NH2:11].CCO>>[CH3:10][NH:11][CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 745704-(Chloromethyl)pyridinium chloride

HCID 22028356Methylamine ethanol

Product 1

HCID 81436N-Methylpyridine-4-methylamineYield 79%

Procedure

Using 4-chloromethyl-pyridine hydrochloride salt and 33% methylamine/EtOH the title compound was obtained as a colourless liquid (0.1 mm Hg, 60-62° C.) (79% yield), MS: m/e=122.1 (M+).

Sources & evidence

ORD record: ord-ab13ef18b52a4cb7b70ae625e949fc95
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07317007B2

Reaction notes

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