Sodium Methoxide → (5-Methoxy-biphenyl-3-yl)-thiourea

HRID 2250788Notes

Reaction equation

HRID 2250788 reaction equation
C([NH:9][C:10]([NH:12][C:13]1[CH:14]=[C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1)=[S:11])(=O)C1C=CC=CC=1.C[O-].[Na+]>CO>[CH3:20][O:19][C:17]1[CH:18]=[C:13]([NH:12][C:10]([NH2:9])=[S:11])[CH:14]=[C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:16]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 222833191-Benzoyl-3-(5-methoxy-biphenyl-3-yl)-thiourea

Product 1

HCID 22283392(5-Methoxy-biphenyl-3-yl)-thioureaYield 88%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Benzoyl-3-(5-methoxy-biphenyl-3-yl)-thiourea (183 mg, 0.51 mmol) in methanol (5 ml) are treated with sodium methoxide (5.4M in methanol, 0.14 ml) and the formed precipitate is filtered off. Washing with methanol yields the product (115 mg, 88%) as off-white powder. MS: m/e=258 (M+).

Workup

  1. filtrationthe formed precipitate is filtered off
  2. washWashing with methanol

Sources & evidence

ORD record
ord-5839654b6f0142cb9858bb4545e168df
Source dataset
uspto-grants-2008_01
Patent number
US07317007B2

Reaction notes

Loading…