HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy-5-nitro-biphenyl → 5-Methoxy-[1,1'-biphenyl]-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy-5-nitro-biphenyl | HCID 22283330 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Methoxy-[1,1'-biphenyl]-3-amine | HCID 22283172 | 91% |
Reaction Steps
3-Methoxy-5-nitro-biphenyl (176 mg, 0.77 mmol) are hydrogenated in ethanol (5 ml) using palladium on carbon (10%, 17 mg) at atmospheric pressure for 2 h. The calalyst is filtered off and the solvent removed in vacuo. Flash chromatography (silica, eluent ethyl acetate/cyclohexane 1:1) affords the product (139 mg, 91%) as a bown oil. MS: m/e=199 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07317007B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-99ed7f8006714ba4958423a72e34301f |
| Source note | uspto-grants-2008_01 |