HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 11480910, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Epothilone A | HCID 448799 | — |
| Reactant | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11480910 | HCID 11480910 | — |
Reaction Steps
1 g (2.03 mmol) of epothilone A is dissolved in 168 mL of CH2Cl2. After adding 86 μl (0.88 mmol) of piperidine and 254 μl (0.88 mmol) of titanium tetra-isopropylate, the reaction solution is strirred for 16 h at RT. After concentration in vacuo, the product is purified by FC (200 g of silica gel, CH2Cl2→CH2Cl2/acetone=4:1) giving a colorless oil: Rf (CH2Cl2/acetone=85:15): 0.55; M+H=494.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07317100B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-41c56c16592940d48acbb9fbd3856ba4 |
| Source note | uspto-grants-2008_01 |