HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-Amino-3-methoxyiminomethyl-3-cephem-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | O-Methylhydroxylamine | HCID 4113 | — |
| Reactant | (6R,7R)-7-amino-3-formyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | HCID 15385898 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-Amino-3-methoxyiminomethyl-3-cephem-4-carboxylic acid | HCID 131710498 | — |
Reaction Steps
A solution of 0.5 g of the hydrochloride of O-methylhydroxylamine in 10 ml of water is treated under stirring at 0° with 1.38 g of 7-amino-3-formyl-3-cephem-4-carboxylic acid and stirred for ca. 8 hours at 0°. 7-Amino-3-[(methoxyimino)methyl]-3-cephem-4-carboxylic acid precipitates in form of almost white crystals, which are filtered off, washed with 5 ml of cold water and 5 ml of acetone and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07317101B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-ebc41becbcc74252b90eb68137909926 |
| Source note | uspto-grants-2008_01 |