Nitric Acid → HCID 59642134, compound

HRID 2250856Notes

Reaction equation

HRID 2250856 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([S:8]([F:13])([F:12])([F:11])([F:10])[F:9])[CH:5]=[C:4]([Br:14])[C:3]=1[O:15][CH3:16].[N+:17]([O-])([OH:19])=[O:18].C([O-])([O-])=O.[Na+].[Na+]>>[Br:1][C:2]1[CH:7]=[C:6]([S:8]([F:13])([F:9])([F:10])([F:11])[F:12])[C:5]([N+:17]([O-:19])=[O:18])=[C:4]([Br:14])[C:3]=1[O:15][CH3:16]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 10340Sodium CarbonateHCID 59642144HCID 59642144, compound

Product 1

HCID 59642134HCID 59642134, compound

Procedure

630 mg of 1,3-dibromo-2-methoxy-5-pentafluorosulfanylbenzene were stirred in 2 ml of a 90% aqueous HNO3 solution at 0° C. for 1 hour. Subsequently, the mixture was stirred at RT for 20 minutes and then poured onto 50 g of ice. An aqueous Na2CO3 solution was used to adjust to pH=6 and extraction was effected three times with 50 ml each of EA. Drying was effected over Na2SO4 and the solvent was removed under reduced pressure. Chromatography on silica gel using 1:3 DIP/HEP afforded 260 mg of a pale yellow oil.

Workup

  1. extractionto adjust to pH=6 and extraction
  2. customDrying
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-5646a877cccc446fb645cd1a940c49a8
Source dataset
uspto-grants-2008_01
Patent number
US07317124B2

Reaction notes

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