Sodium Carbonate → HCID 11525014, compound

Participants

Reaction Steps

A solution of benzoic acid N′-[2-(2-bromo-4-cyano-phenoxy)-acetyl]-N′-isopropyl-hydrazide (200 mg, 0.480 mmol) in DME (3 ml)/2M Na2CO3 (0.840 ml, 1.68 mmol) was treated with 2-ethylphenylboronic acid (144 mg, 0.9608 mmol) and Pd[PPh3]4 (55 mg, 0.048 mmol) in a microwave oven at 150° C. for 10 min. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered, and concentrated. The crude was absorbed on silica and purified on a silica gel column with 30% ethyl acetate/hexanes to afford the product as a white solid (177 mg, 84%). MS m/e 442.25 (M+H+)

Provenance & Evidence