HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,7-Dichloroindoline → 5-Chloro-1-[(1R)-1-cyclopropylpropyl]-3-(5,7-dichloro-2,3-dihydro-1H-indol-1-yl)-2(1H)-pyrazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,7-Dichloroindoline | HCID 12482295 | — |
| Reactant | 1-[(1R)-1-cyclopropylpropyl]-3,5-dichloro-2(1H)-pyrazinone | HCID 18452799 | — |
| Product | 5-Chloro-1-[(1R)-1-cyclopropylpropyl]-3-(5,7-dichloro-2,3-dihydro-1H-indol-1-yl)-2(1H)-pyrazinone | HCID 10135525 | — |
Reaction Steps
Prepared in a similar fashion as described for Example 413 using 3,5-dichloro-1-[(1R)-1-cyclopropylpropyl]-2(1H)-pyrazinone and 5,7-dichloroindoline as the starting materials. mp 166-168° C.; 1H NMR (300 MHz, CDCl3): δ 7.15 (s, 1 H), 7.09 (s, 1 H), 6.99 (s, 1 H), 4.34-4.24 (m, 2 H), 4.08-3.99 (m, 1 H), 3.11 (t, J=8.1 Hz, 2H), 2.12-2.05 (m, 1 H), 1.92-1.76 (m, 1 H), 1.05-1.00 (m, 1 H), 0.94-0.86 (m, 3 H), 0.80-0.71 (m, 1 H), 0.53-0.46 (m, 2 H), 0.33-0.21 (m, 1 H); HRMS (ESI) calcd for C18H19N3OCl3 (M+H)+: 398.0594; found m/z 398.0575.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07319100B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-d95353e54b4541eda6c6609e211f4a2c |
| Source note | uspto-grants-2008_01 |