HCID 18452785, compound → HCID 10224023, compound

Participants

Reaction Steps

Prepared in a similar fashion as described for Example 536 using 1-(1-cyclobutylpropyl)-3,5-dichloro-6-methyl-2(1H)-pyrazinone and 5-methoxy-7-methylindoline hydrochloride as the starting materials to give a yellow amorphous solid; 1H NMR (300 MHz, CDCl3) δ 6.73 (s, 2H), 4.28 (t, J=8.4 Hz, 2H), 4.04-3.97 (m, 1H), 3.79 (s, 3H), 3.62-3.55 (m, 1H), 3.10 (t, J=7.7 Hz, 2H), 2.50 (s, 3H), 2.42-2.35 (m, 1H), 2.22-2.10 (m, 1H), 1.90-1.50 (m, 5H), 1.58-1.50 (m, 1H), 0.86 (t, J=7.3 Hz, 3H); HRMS (ESI) m/z 422.1420 [(M+H)+, calcd for C21H26N3O2Cl2 422.1402].

Provenance & Evidence