反应详情

温度

0 °C

Dissolve 2-carboxy-indan (2.5 g, 15.4 mmol) in methanol and cool to 0° C. Saturate with hydrochloride gas then add 2,2-dimethoxypropane (2-3 mL). Stir overnight then evaporate the solvent in vacuo. Purify by silica gel chromatography (2:1 methylene chloride/hexane) to give 2-carbomethoxy-indan as a water white oil. (2.04 g, 75%).

1. concentrationSaturate with hydrochloride gas
2. customthen evaporate the solvent in vacuo
3. customPurify by silica gel chromatography (2:1 methylene chloride/hexane)