Pyrazol-3-ylamine → HCID 178515163, compound

HRID 2251102Notes

Reaction equation

HRID 2251102 reaction equation
CO[C:3]([CH:5]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:6]1=O)=[O:4].[N:13]1[NH:14][C:15]([NH2:18])=[CH:16][CH:17]=1>C(O)(=O)C>[N:13]1[N:14]2[C:15]([N:18]=[C:6]3[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:5]3=[C:3]2[OH:4])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 74561Pyrazol-3-ylamineHCID 288225Methyl 2-oxocycloheptane-1-carboxylate

Product 1

HCID 178515163HCID 178515163, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2-oxo-cycloheptanecarboxylic acid methyl ester (5 g, 29.4 mmol) and 2H-pyrazol-3-ylamine (2.44 g, 29.4 mmol) in acetic acid (5 mL) was heated at 100° C. for 1 hour and resulted in the formation of a colorless precipitate. The solid was collected via filtration and washed with ethanol and ethyl ether to give 6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]inden-10-ol (5 g, 85% yield). The product was used without further purification.

Workup

  1. customresulted in the formation of a colorless precipitate
  2. filtrationThe solid was collected via filtration
  3. washwashed with ethanol and ethyl ether

Sources & evidence

ORD record
ord-acaa47301d8c4db1a325283a6c15f47f
Source dataset
uspto-grants-2008_01
Patent number
US07319103B2

Reaction notes

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