4-Benzyloxy-phenylboronic acid → 9-(4-Benzyloxy-phenyl)-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline

HRID 2251110Notes

Reaction equation

HRID 2251110 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]3[C:20]([N:21]=[C:22]4[CH2:28][CH2:27]C[CH2:25][CH2:24][C:23]=24)=[CH:19][CH:18]=[N:17]3)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC1N2N=CC=C2N=C2C=1CCCC2.C(OC1C=CC(B(O)O)=CC=1)C1C=CC=CC=1>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]3[N:17]=[CH:18][CH:19]=[C:20]3[N:21]=[C:22]3[C:23]=2[CH2:24][CH2:25][CH2:27][CH2:28]3)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 27343144-Benzyloxy-phenylboronic acidHCID 5858771710-(4-benzyloxy-phenyl)-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indeneHCID 638208079-Chloro-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline

Product 1

HCID 692562319-(4-Benzyloxy-phenyl)-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline

Procedure

Using the method described for the preparation of 10-(4-benzyloxy-phenyl)-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene, the reaction of 9-chloro-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline and 4-benzyloxyphenyl boronic acid provided the title compound.

Sources & evidence

ORD record
ord-cd9028d1f15942349665172b9cbcfe2a
Source dataset
uspto-grants-2008_01
Patent number
US07319103B2

Reaction notes

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