(4-Benzyloxy-phenyl)-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline → 4-(5,6,7,8-Tetrahydro-pyrazolo[5,1-b]quinazolin-9-yl)-phenol

HRID 2251111Notes

Reaction equation

HRID 2251111 reaction equation
[N:1]1[N:9]2[C:4]([N:5]=[C:6]3[CH2:21][CH2:20][CH2:19]C[CH2:17][C:7]3=[C:8]2[C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[CH:3][CH:2]=1.C(OC1C=CC(C2C=C3N=C4C(=CN3N=2)CCCC4)=CC=1)C1C=CC=CC=1.[H][H]>[Pd]>[N:1]1[N:9]2[C:4]([N:5]=[C:6]3[C:7](=[C:8]2[C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[CH2:17][CH2:19][CH2:20][CH2:21]3)=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 69256228(4-Benzyloxy-phenyl)-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazolineHCID 1360572464-(6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]inden-10-yl)-phenolHCID 178418361HCID 178418361, compound

Product 1

HCID 1363610224-(5,6,7,8-Tetrahydro-pyrazolo[5,1-b]quinazolin-9-yl)-phenol

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the method described for the preparation of 4-(6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]inden-10-yl)-phenol, (4-benzyloxy-phenyl)-5,6,7,8-tetrahydro-pyrazolo[5,1-b]quinazoline and hydrogen in the presence of 10% Pd/C provided the title compound.

Sources & evidence

ORD record
ord-229daf8775424cc591c051f886224d84
Source dataset
uspto-grants-2008_01
Patent number
US07319103B2

Reaction notes

Loading…