(3S)-pyrrolidin-3-ol → 1-{3-[4-(6,7-Dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-phenoxy]-propyl}-pyrrolidin-3-(S)-ol

Participants

Role	Name	HCID	Charge
Reactant	(3S)-pyrrolidin-3-ol	HCID 2733874	—
Reactant	10-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene	HCID 11611130	—
Reactant	8-[4-(3-Chloro-propoxy)-phenyl]-6,7-dihydro-5H-1,4,8a-triaza-s-indacene	HCID 69255812	—
Product	1-{3-[4-(6,7-Dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-phenoxy]-propyl}-pyrrolidin-3-(S)-ol	HCID 58587721	—

Reaction Steps

Using the method described for the preparation of 10-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene, the reaction of 8-[4-(3-chloro-propoxy)-phenyl]-6,7-dihydro-5H-1,4,8a-triaza-s-indacene and 3-(S)-hydroxy-pyrrolidine provided the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07319103B2
Source dataset	uspto-grants-2008_01
ORD ID	ord-854fc7ede6424ba2b30a878a21353565
Source note	uspto-grants-2008_01