(R)-2-Methylpyrrolidine → HCID 58587716, compound

HRID 2251122Notes

Reaction equation

HRID 2251122 reaction equation
[CH3:1][CH:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[N:18]3[C:22]([N:23]=[C:24]4[CH2:30][CH2:29][CH2:28]CC[C:25]=24)=[CH:21][CH:20]=[N:19]3)=[CH:13][CH:12]=1.[Cl:31]C1C=C(C2N3C(=CC=N3)N=C3C=2CCC3)C=CC=1OCCCCl.C[C@@H]1CCCN1>>[Cl:31][C:12]1[CH:13]=[C:14]([C:17]2[N:18]3[C:22](=[CH:21][CH:20]=[N:19]3)[N:23]=[C:24]3[C:25]=2[CH2:28][CH2:29][CH2:30]3)[CH:15]=[CH:16][C:11]=1[O:10][CH2:9][CH2:8][CH2:7][N:3]1[CH2:4][CH2:5][CH2:6][C@H:2]1[CH3:1]

Participants

4

Reactant 3

HCID 641544(R)-2-MethylpyrrolidineHCID 1161113010-{4-[3-(2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indeneHCID 69255907HCID 69255907, compound

Product 1

HCID 58587716HCID 58587716, compound

Procedure

Using the method described for the preparation of 10-{4-[3-(2-Methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-6,7,8,9-tetrahydro-5H-1,4,10a-triaza-cyclohepta[f]indene, the reaction of 8-[(3-chloro)-4-(3-chloro-propoxy)-phenyl]-6,7-dihydro-5H-1,4,8a-triaza-s-indacene and 2-(R)-methyl-pyrrolidine provided the title compound.

Sources & evidence

ORD record
ord-ed76616360c44ec0aadca952d9fcfd57
Source dataset
uspto-grants-2008_01
Patent number
US07319103B2

Reaction notes

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