Water → methanesulfonic acid 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzo-furan-2-yl]-ethyl ester

Participants

Reaction Steps

To a room temperature solution of 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzofuran-2-yl]-ethanol (200 mg, 0.91 mmol) in CH2Cl2 (10 ml) was added triethylamine (303 mg, 3 mmol) and methanesulfonyl chloride (525 mg, 4.56 mmol). The mixture was stirred at room temperature for 30 minutes. Water was added to the reaction and the organic layer separated. The aqueous layer was extracted with CH2Cl2 and the combined organic extracts were dried and concentrated to give methanesulfonic acid 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzo-furan-2-yl]-ethyl ester, which was used in the next reaction without further purification.

Provenance & Evidence