Potassium Hydroxide → 1,10-Phenanthroline

Participants

Reaction Steps

4.0 g of propellane, 3.3 g of aluminium chloride and 2.0 ml of acetyl chloride were added to 200 ml of 1,2-dichloroethane, and reaction carried out for 1.5 hours at room temperature and then for 6 hours at 60° C. By treatment in the normal way, 3.26 g of the triacetyl-propellane was obtained. 1.41 g of this triacetyl derivative was reacted with 1.50 g of 8-amino-7-quinolinecarbaldehyde and 1.5 g of potassium hydroxide in dioxane at 60° C. and, by treatment in the normal way, Phen-5 (1.32 g) shown below was obtained.

Provenance & Evidence