Potassium Hydroxide → 1,8-Naphthyridine

Participants

Reaction Steps

0.77 g of diacetyltetraphenylmethane obtained by the method described in Example 7 was reacted with 0.51 g of 2-aminonicotinaldehyde and 0.76 g of potassium hydroxide in dioxane and, by treatment in the normal way, TPM-dNTR (0.82 g) shown below was obtained. 1H-NMR (CDCl3, ppm): 9.12 (d·d, 2H), 8.27−8.16 (m, 8H), 8.00 (d, 2H), 7.49−7.44 (m, 6H), 7.34−7.23 (m, 10H)

Provenance & Evidence