1-(3-Aminopropyl)-2-pipecoline → HCID 69277922, compound

HRID 2251145Notes

Reaction equation

HRID 2251145 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([OH:17])=O)[CH:11]=2)[C:6]1=[O:18].[CH3:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][N:25]1[CH2:30][CH2:31][CH2:32][NH2:33]>>[Cl-:1].[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([NH:33][CH2:32][CH2:31][CH2:30][NH+:25]3[CH2:26][CH2:27][CH2:28][CH2:29][CH:24]3[CH3:23])=[O:17])[CH:11]=2)[C:6]1=[O:18]

Participants

3

Reactant 2

HCID 5202111-(3-Aminopropyl)-2-pipecolineHCID 2994323HCID 2994323, compound

Product 1

HCID 69277922HCID 69277922, compound

Procedure

2-(2-chloro-benzyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-carboxylic acid (100 mg, 0.316 mmol) and 3-(2-methylpiperidin-1-yl)propan-1-amine (138 μL, 0.792 mmol) were reacted with each other. Target compound in the amount of 92 mg (60%) was obtained by following the procedure described in Example 1.

Workup

  1. customTarget compound in the amount of 92 mg (60%) was obtained

Sources & evidence

ORD record
ord-696c190fe6b34828a36174e417637d7f
Source dataset
uspto-grants-2008_01
Patent number
US07319098B2

Reaction notes

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